PHSI3011 11-2 Liver in Metabolic Homeostasis

Question 1 of 31

1

Glycolysis turns ❌ into ❌.

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Glucose-6-P

Pyruvate

Glucose

Glycogen

Lactate

Glycerol

Amino Acids

Explanation

Question 2 of 31

1

Glycogenesis turns ❌ into ❌.

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Glucose-6-P

Pyruvate

Lactate

Glucose

Glycerol

Amino Acids

Glycogen

Explanation

Question 3 of 31

1

Gluconeogenesis turns ❌ into ❌.

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Pyruvate

Glucose-6-P

Glucose

Glycogen

Glucagon

Explanation

Question 4 of 31

1

Glycogenolysis turns ❌ into ❌.

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Glycogen

Glucose-6-P

Pyruvate

Glucose

Lactate

Glycerol

Glucagon

Amino Acids

Explanation

Question 5 of 31

1

The three rate-limiting steps of Gluconeogenesis are:

Select one or more of the following:

Glucose 6-Phosphatase
Fructose 1,6-bisphosphatase
PEP carboxykinase
Pyruvate kinase
Phosphofructokinase-1
Hexokinase

Explanation

Question 6 of 31

1

The three rate-limiting steps of Glycolysis are:

Select one or more of the following:

Glucose 6-Phosphatase
Fructose 1,6-bisphosphatase
PEP carboxykinase
Pyruvate kinase
Phosphofructokinase-1
Hexokinase

Explanation

Question 7 of 31

1

Which one is which: Glycolysis vs Gluconeogenesis

Drag an answer into the correct orange point.

Gluconeogenesis

Glycolysis

Explanation

Question 8 of 31

1

Put the three rate-limiting steps (of each side) in the right places.

Drag an answer into the correct orange point.

Glucose 6-Phosphatase

Fructose 1,6-bisphosphatase

PEP carboxykinase

Hexokinase

Phosphofructokinase-1

Pyruvate kinase

Explanation

Question 9 of 31

1

Does insulin STIMULATE or SUPPRESS glucose disposal and glycogen&lipid synthesis?

Select one of the following:

Stimulate
Suppress

Explanation

Question 10 of 31

1

Does insulin STIMULATE or SUPPRESS glucose production and VLDL secretion?

Select one of the following:

Stimulate
Suppress

Explanation

Question 11 of 31

1

What’s a LIRKO?

Select one of the following:

Liver-specific Insulin Receptor KnockOut mouse
Loss of Insulin Receptor KnockOut mouse
Liver-specific Insulin Receptor Knockout Organism
Loss of Insulin Receptor Knockout Organism

Explanation

Question 12 of 31

1

What results in a LIRKO in regards to blood&serum glucose levels?

Select one of the following:

Blood increase; serum increase
Blood increase; serum decrease
Blood decrease; serum increase
Blood decrease; serum decrease

Explanation

Question 13 of 31

1

Loss of PTEN expression in the liver results in increased Liver Triglyceride levels. What’s PTEN?

Select one of the following:

Phosphatase and TENsin homolog
Phosphatase and TENsin ligand
Phosphatase and TENsin binding factor
Phosphatase and TENsin lipase

Explanation

Question 14 of 31

1

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Glucose is taken up in a GLUT2-dependent manner. It’s then stored as ( Glycogen, Glucose 6-Phosphate, Pyruvate, Glucagon, Glycerol ) until blood glucose levels drop.

Explanation

Question 15 of 31

1

The liver contributes to the homeostasis of circulating levels of which?

Select one or more of the following:

Fatty Acids
Cholesterol

Explanation

Question 16 of 31

1

The liver is the main clearance tissue for removal of Fatty Acids from circulation, then repackages them in what?

Select one of the following:

VLDL-TAG
LDL-TAG
HDL-TAG
Chylomicron-TAG

Explanation

Question 17 of 31

1

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Stages of Lipoprotein and FA uptake:
( Stage 1, Stage 2, Stage 3 ) – ( Hepatic lipase (and Lipoprotein lipase), Periphery, Liver ) resides on endothelial cells to hydrolyse VLDL-TAG to FAs for uptake

Explanation

Question 18 of 31

1

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Stages of Lipoprotein and FA uptake:
( Stage 1, Stage 2, Stage 3 ) – ( Hepatic lipase (and Lipoprotein lipase), Periphery, Liver ): TAG-rich VLDL interacts with VLDL-R, enters lysosomal pathway for hydrolysis and TAG synthesis.

Explanation

Question 19 of 31

1

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Stages of Lipoprotein and FA uptake:
( Stage 1, Stage 2, Stage 3 ) – ( Hepatic lipase (and Lipoprotein lipase), Periphery, Liver ): VLDL-remnants interact with a range of receptors for endocytosis.

Explanation

Question 20 of 31

2

Fatty Acid metabolism. The major pathways are:
De novo lipogenesis: ❌
TriAcylGlycerol metabolism: ❌
β-Oxidation: ❌

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Synthesis of fatty acids from non-lipid

Esterification, Lipoprotein and Lipolysi

FA-CoA >> acetyl-CoA

Explanation

Question 21 of 31

1

Fatty Acid Metabolism: loss of Lipolysis-Stimulated Receptor (LSR) expression does what?

Select one or more of the following:

Increase in Serum TriGlyceride levels
Decrease in Liver TriGlyceride levels
Decrease in Serum TriGlyceride levels
Increase in Liver TriGlyceride levels

Explanation

Question 22 of 31

4

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Loss of CD36 in the liver leads to ( Increased, Unaffected, Reduced ) Plasma FA levels. Plasma FAs ( Inhibit, Stimulate ) LPL activity. Therefore loss of CD36 ( Reduces, Increases ) Chylomicron/VLDL-TAG hydrolysis (breakdown). …Leading to ( Accumulation, Shortage ) of TAG in the circulation.

Explanation

Question 23 of 31

1

True or false: The Hepatokine ILGF stands for Insulin-Like Growth Factor.

Select one of the following:

True
False

Explanation

Question 24 of 31

1

Click on the orange point and select the correct answer.

What's this bit called?

Explanation

Question 25 of 31

1

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What's this bit called?

Explanation

Question 26 of 31

1

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What's this bit called?

Explanation

Question 27 of 31

1

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What's this bit called?

Explanation

Question 28 of 31

1

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What could be here?

Explanation

Question 29 of 31

1

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What could be here?

Explanation

Question 30 of 31

1

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What could be here?

Explanation

Question 31 of 31

1

	Created by Michael Jardine about 8 years ago

PHSI3011 11-2 Liver in Metabolic Homeostasis

PHSI3011 11-2 Liver in Metabolic Homeostasis

Question 1 of 31

Glycolysis turns ❌ into ❌.

Drag and drop to complete the text.

Explanation

Question 2 of 31

Glycogenesis turns ❌ into ❌.

Drag and drop to complete the text.

Explanation

Question 3 of 31

Gluconeogenesis turns ❌ into ❌.

Drag and drop to complete the text.

Explanation

Question 4 of 31

Glycogenolysis turns ❌ into ❌.

Drag and drop to complete the text.

Explanation

Question 5 of 31

The three rate-limiting steps of Gluconeogenesis are:

Select one or more of the following:

Explanation

Question 6 of 31

The three rate-limiting steps of Glycolysis are:

Select one or more of the following:

Explanation

Question 7 of 31

Which one is which: Glycolysis vs Gluconeogenesis

Drag an answer into the correct orange point.

Explanation

Question 8 of 31

Put the three rate-limiting steps (of each side) in the right places.

Drag an answer into the correct orange point.

Explanation

Question 9 of 31

Does insulin STIMULATE or SUPPRESS glucose disposal and glycogen&lipid synthesis?

Select one of the following:

Explanation

Question 10 of 31

Does insulin STIMULATE or SUPPRESS glucose production and VLDL secretion?

Select one of the following:

Explanation

Question 11 of 31

What’s a LIRKO?

Select one of the following:

Explanation

Question 12 of 31

What results in a LIRKO in regards to blood&serum glucose levels?

Select one of the following:

Explanation

Question 13 of 31

Loss of PTEN expression in the liver results in increased Liver Triglyceride levels. What’s PTEN?

Select one of the following:

Explanation

Question 14 of 31

Select from the dropdown list to complete the text.

Glucose is taken up in a GLUT2-dependent manner. It’s then stored as Glycogen Glucose 6-Phosphate Pyruvate Glucagon Glycerol( Glycogen, Glucose 6-Phosphate, Pyruvate, Glucagon, Glycerol ) until blood glucose levels drop.

Explanation

Question 15 of 31

The liver contributes to the homeostasis of circulating levels of which?

Select one or more of the following:

Explanation

Question 16 of 31

The liver is the main clearance tissue for removal of Fatty Acids from circulation, then repackages them in what?

Select one of the following:

Explanation

Question 17 of 31

Select from the dropdown lists to complete the text.

Stages of Lipoprotein and FA uptake: Stage 1 Stage 2 Stage 3( Stage 1, Stage 2, Stage 3 ) – Hepatic lipase (and Lipoprotein lipase) Periphery Liver( Hepatic lipase (and Lipoprotein lipase), Periphery, Liver ) resides on endothelial cells to hydrolyse VLDL-TAG to FAs for uptake

Explanation

Question 18 of 31

Select from the dropdown lists to complete the text.

Explanation

Question 19 of 31

Select from the dropdown lists to complete the text.

Stages of Lipoprotein and FA uptake: Stage 1 Stage 2 Stage 3( Stage 1, Stage 2, Stage 3 ) – Hepatic lipase (and Lipoprotein lipase) Periphery Liver( Hepatic lipase (and Lipoprotein lipase), Periphery, Liver ): VLDL-remnants interact with a range of receptors for endocytosis.

Explanation

Question 20 of 31

Fatty Acid metabolism. The major pathways are: De novo lipogenesis: ❌ TriAcylGlycerol metabolism: ❌ β-Oxidation: ❌

Drag and drop to complete the text.

Glucose is taken up in a GLUT2-dependent manner. It’s then stored as ( Glycogen, Glucose 6-Phosphate, Pyruvate, Glucagon, Glycerol ) until blood glucose levels drop.

Stages of Lipoprotein and FA uptake:
( Stage 1, Stage 2, Stage 3 ) – ( Hepatic lipase (and Lipoprotein lipase), Periphery, Liver ) resides on endothelial cells to hydrolyse VLDL-TAG to FAs for uptake

Stages of Lipoprotein and FA uptake:
( Stage 1, Stage 2, Stage 3 ) – ( Hepatic lipase (and Lipoprotein lipase), Periphery, Liver ): VLDL-remnants interact with a range of receptors for endocytosis.

Fatty Acid metabolism. The major pathways are:
De novo lipogenesis: ❌
TriAcylGlycerol metabolism: ❌
β-Oxidation: ❌