14045727
| Question | Answer |
| Trade names | Kefzol - Cefazolin |
| Chemical name | Cephazolin sodium |
| Therapeutic class | anti-infective |
| Pharmaceutical class | antibiotic - cephalosporin |
| Indications | -Staphylococcal and streptococcal infections in people with mild-to-moderate penicillin allergy -Surgical prophylaxis -UTI |
| Action | Bactericidal; interferes with bacterial cell wall peptidoglycan synthesis by binding to penicillin-binding proteins, eventually leading to cell lysis and death. |
| Absorption | Not well absorbed in GIT - given via IV for optimal absorption |
| Distribution | Does cross placenta and into breastmilk - however is said to be safe |
| Metabolism & excretion | Excreted unchanged in urine |
| Half-life | 1.8 hours |
| contraindications/precautions | -Some people who are allergic to penicillins are also allergic to cephalosporins -Those with heart failure or on sodium restriction - high levels of sodium -Immunocompromised individuals = high incidence of rash -Renal impairment |
| Adverse reactions | Skin: rash GIT: diarrhoea, N + V, CNS: neurotoxicity at high doses/ renal impairment |
| Drug interactions | May increase the effect of anticoagulants such as warfarin |
| Nursing assessment implications | -Obtain specimen for culture -Baseline vital signs -Monitor person's response to administration |
| Education | Tell patients to report adverse effects drink lots of fluids, and keep up nutrition |
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