14120244
| Question | Answer |
| The steps in pharmacokinetics | DADME Dissolution Absorption Distribution Metabolism Excretion |
| Dissolution | Easily dissolved in the stomach and GIT |
| Absorption | Quickly and readily absorbed by the GIT into circulation |
| Distribution | Quickly distributed across the body (3 - 6 hour half-life) Can cross the blood-brain barrier, and cross the placenta as well as enter breast milk. |
| Metabolism | Has a 50% oral bioavailability due to the first pass effect - readily metabolised by the liver - into three different metabolites |
| Excretion | Extensively (95%) excreted by the kidneys as metabolites and a small amount of unmetabolised drug |
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