Antifungals

Question	Answer
Antifungal agent	A drug that selective eliminates fungal pathogens
Antifungal relation to Antibacterial?	There are far less antifungal agents than antibacterial agents
Major/examples antifungal agents	Polyene macrolides Imidazoles Flucytosine Griseofulvin Iodides
Polyene macrolides; Drug names	Amphotericin B Nystatin Pimaricin (natamycin)
Polyene macrolides; Mode of Action	Bing Sterol-components in phospholipid sterol membranes. [Disrupts membranes]
What's unique about Polyene macrolides at a pH between 6-7.3	Fungicidal>fungistatic
When do you use Amphotericin B?	Principally; Systemic mycotic infections
Tx?; Nystatin [Polyene macrolide]	Tx/Nystatin: Mucocutaneous (skin, oropharynx, vagina) or Intestinal Candidiasis
Tx:Pimaricin? [Polyene macrolides]	Pimaricin: Therapeutic management of mycotic keratitis
Imidazoles-uses	Anti-bacterial, Anti-fungal, Anti-protozoal, Anti-helmintic activity

Resource summary

	Created by Justin Veazey almost 11 years ago