1802588
| Question | Answer |
| Clinical action limit | Limit when GPs must start treatment |
| +/- 1SD =? % population? For 2? For 3? | +/- 1SD = 68% +/- 2SD = 95% +/- 3SD = 99% |
| Critical Difference | How much something has to change before it is considered a pathological shift. |
| Formula for Critical Difference? | CD= 2.8 x SQRT(SDa^2 +SDb^2) |
| What is the assumption of the Therapeutic window? | Assumes that the desired and undesired effects are related to the drug concn |
| When is a drug w/ a narrow therapeutic window acceptable? | If disease is life-threatening |
| What do half-lives influence? | - Dosing interval - Implications of missed dose -Implications of stopping drug |
| Clearance is influenced by? | - Routes of metabolism - Routes of excretion - Distribution into other body compartments |
| Different tissues = diff profusion rates Example? | Heart, kidney, lung muscle, skin, adipose bone, teeth |
| Dosing intervals of how many half lives until drug accumulation? | <4 |
| Bioavailability formula? | F= AUC extravascular/AUC IV |
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