18153340
Description
Flashcards by Simeon Crane, updated more than 1 year ago
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Created by Simeon Crane
over 6 years ago
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| Question | Answer |
| What are the two major components of toothpastes? | Humectants and abrasives |
| What is the most commonly used benzodiazepine antagonist in the UK? | Flumazenil |
| What is the major predisposing factor for paradoxical effects of benzodiazepines? | Alcoholism |
| What does a simple suppository contain? | Fine particles of drug suspended in a melted base |
| What drug is first line treatment for absence seizures? | Ethosuximide |
| How does diphenhydramine cause drowsiness? | It antagonises the 5-HT1A receptor in the brain |
| What is the drug target of benzodiazepines? | The GABA-A receptor |
| What is the most common neurotransmitter? | GABA |
| What are the two most common Glutamate receptors? | NMDA receptors AMPA receptors |
| What protein does Levetiracetam target? | SV2A |
| What are the two main types of seizures? | - Focal - Generalized |
| How does carbamazepine and phenytoin work in treating epilepsy? | Lowers neuronal excitability by blocking voltage gated sodium channels in the presynaptic neurons |
| What are the two targets of Sodium Valproate? | Voltage-gated sodium channels LVA, T-type calcium channels |
| What subunit of the HVA calcium channels do pregabalin and gabapentin bind to? | alpha-2 delta-1 |
| What is the mechanism of action of Felbamate? | Inhibits excitatory neurotransmission by blocking NMDA receptors |
| What two classes of drugs, used to treat epilepsy, bind to the GABA-A receptor and prolong its opening? | Benzodiazepines Barbiturates |
| What is the mechanism of action of Vigabatrin? | Inhibits GABA- aminotransferase |
| What two antiepileptics can cause hyponatremia? | Carbamazepine Oxcarbazepine |
| What two antiepileptics can cause double vision? | Lamotrigine Phenytoin |
| Name 4 side effects of sodium valproate | - Sedation - Dizziness - Weight Gain - Liver Toxicity |
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