2261564
Description
Flashcards by wade.barrett777, updated more than 1 year ago
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Created by wade.barrett777
over 10 years ago
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| Question | Answer |
| Polyene macrolides | Amphotericin B Nystatin |
| Examples of Imidazoles | Clotrimazole Ketoconazole Miconazole |
| Examples of Triazoles | Fluconazole Itraconazole |
| Aspergillus fumigatos | Pulmonary or Disseminated aspergillosis |
| Cryptococcus neoformans | Cryptococcal meningitis Pulmonary infections |
| Immunocompromised patients | AIDS Corticosteroids Anti-cancer drugs |
| Candida albicans | Oropharyngeal candidiasis (thrush) Endocarditis Vaginitis |
| Amphotericin + Flucytosine can combine to treat | Systemic candidiasis Cryptococcal meningitis |
| Ketoconazole | Good oral absorption Treat local & systemic mycoses Adverse: hepatic necrosis & adrenal suppression |
| Miconazole | Alternative to amphotericin Administered IV to treat systemic mycoses SEs: N&V |
| Mycoses | Fungal infections |
| Fluconazole | Treat superficial & systemic mycoses (except Aspergillus) Administered IV or Orally Not hepatoxic & doesn't cause adrenal suppression like ketoconazole |
| Itraconazole | Good oral absorption Active against Aspergillus |
| Amphotericin | Poor oral absorption Administer IV or Intrathecally (CNS infections) 1st -line: Systemic infections (Candida, Aspergillus & Cryptococcus) |
| Nystatin | Toxic parenterally: i) Suck tablets ii) Pessaries iii) Cream or ointment Treat skin & mucous membrane infection due to C. albicans |
| Flucytosine | Good oral absorption Sytemic Cryptococcal or Candida infections |
| Imidazoles | Often for topical use Treat infections due to dermatophytes OR C. albicans Not effective against Aspergillus |
| Examples of Allylamines | Terbinafine Naftifine |
| Flucytosine compared to Amphotericin, is | Less toxic |
| Liposomal formulation of Amphotericin | Amphotericin B (Liposomal): AmBisome |
| List anti-fungal drug classes that inhibit fungal membrane formation | Allylamines Azoles (Imidazoles & Triazoles) |
| Ketoconazole interaction | Inhibits cytochrome P450 enzymes responsible for inactivating cyclosporine Concentration of cyclosporine increases as a result |
| Adminstered IV, these drugs can cause Thrombophlebitis | Amphotericin B Miconazole |
| Drugs that can cause HA | Amphotericin Itraconazole Griseofulvin |
| Ketoconazole Pregnancy Category | Pregnancy category C (Use not recommended during pregnancy) |
| Induces cytochrome P450 | Griseofulvin |
| Common SEs of Griseofulvin | HA Mental confusion |
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