40175017
Description
Flashcards by Ginger Scally, updated 9 months ago
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Created by Ginger Scally
9 months ago
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| Question | Answer |
| Where does the Krebs cycle occur? | In the mitochondrial matrix. |
| What are the net products per Acetyl-CoA in the Krebs cycle? | 3 NADH, 1 FADH₂, 1 GTP, and 2 CO₂. |
| What are the net products per glucose? | 6 NADH, 2 FADH₂, 2 GTP, and 4 CO₂ |
| What is the mnemonic for Krebs Cycle intermediates? | "Oh Can I Keep Studying Science For Medical School” (Oxaloacetate, Citrate, Isocitrate, α-Ketoglutarate, Succinyl-CoA, Succinate, Fumarate, Malate) |
| At which steps is NADH produced in the Krebs cycle? | Step 3 (Isocitrate Dehydrogenase), Step 4 (α-Ketoglutarate Dehydrogenase), Step 8 (Malate Dehydrogenase). |
| At which step is FADH₂ produced? | Step 6 (Succinate Dehydrogenase). |
| At which step is GTP (or ATP) produced? | Step 5 (Succinyl-CoA Synthetase). |
| What is the rate-limiting enzyme of the Krebs cycle? | Isocitrate Dehydrogenase. |
| What activates and inhibits Isocitrate Dehydrogenase? | Activated by ADP and Ca²⁺; Inhibited by ATP and NADH. |
| What are the three key regulatory enzymes in the Krebs cycle? | Citrate Synthase (Step 1), Isocitrate Dehydrogenase (Step 3), α-Ketoglutarate Dehydrogenase (Step 4). |
| Where do NADH and FADH₂ go after the Krebs cycle? | They enter the Electron Transport Chain (ETC) to produce ATP. |
| How much ATP does NADH yield? | A: 2.5 ATP per NADH. |
| How much ATP does FADH₂ yield? | 1.5 ATP per FADH₂. |
| How much ATP is generated from the Krebs cycle per glucose? | 20 ATP total: • 6 NADH → 15 ATP • 2 FADH₂ → 3 ATP • 2 GTP → 2 ATP |
| What is the only enzyme of the Krebs cycle located in the inner mitochondrial membrane? | Succinate Dehydrogenase. |
| What inhibits α-Ketoglutarate Dehydrogenase? | ATP, NADH, and Succinyl-CoA. |
| What activates α-Ketoglutarate Dehydrogenase? | Ca²⁺. |
| What is the mnemonic for Krebs cycle regulation? | "ATP and NADH Stop; ADP and Ca²⁺ Go!" (ATP and NADH inhibit; ADP and Ca²⁺ activate.) |
| How much ATP is generated from one turn of the Krebs cycle? | 10 ATP per Acetyl-CoA. |
| How much ATP is generated from the Krebs cycle per glucose? | 20 ATP per glucose. |
| What is the mnemonic for the Krebs Cycle enzymes? | Cool Aunts In Kansas Sell Special Fudge Monthly (Citrate synthase, Aconitase, Isocitrate dehydrogenase, Alpha Ketoglutarate dehydrogenase, Succinyl CoA synthetase, Succinate dehydrogenase, Fumarase, Malate dehydrogenase) |
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