408999
Description
Flashcards by gina_evans0312, updated more than 1 year ago
|
Created by gina_evans0312
almost 12 years ago
|
|
| Question | Answer |
| Oncogene | Gene who's abnormal/mutated expression causes production of a malignant phenotype |
| Proto-oncogene | Cellular homologue from which oncogene is derived |
| Tumor Suppressor | Encodes a protein restricting cell growth |
| Conversion to Oncogene - Deletion/Point mutation | Normal amounts of hyperactive proteins |
| Conversion to Oncogene - Gene Fusion | Hyperactive fusion protein |
| Conversion to Oncogene - Chromosome Rearrangement | Varies- Near a strong promoter, you get increased levels of normal protein |
| Conversion to Oncogene - Gene Replication | Amplified levels of normal protein |
| No of Oncogene Classifications (At G0/G1 border | 4 |
| Competence Factors | Increases production of cell cycle regulators |
| Example of a Progression Factor | EGF, PDGF, FGF |
| Progression Factors | Must increase in conjunction with CF's, or the CF's are degraded and the cell remains in G0 |
| Example of Progression Factors | Insulin or IGF1 |
| Inhibitor Factors | Prevent accidental entering of mitotic cycle (must be absent for G1 to be entered) |
| Example of Inhibitory Factors | TGFB |
| Acutely Transforming Retroviruses | Viruses containing a viral oncogene |
| No of Class of Tyrosine Kinase | 9- each has different signalling molecules |
Want to create your own Flashcards for free with GoConqr? Learn more.