792779
Description
Flashcards by Livvi Harris, updated more than 1 year ago
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Created by Livvi Harris
over 11 years ago
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| Question | Answer |
| Fostamatinib R343 | Syk inhibitors |
| Rilonacept | IL-1 trap (FOAS) |
| Anakinra | Recombinant IL-1ra |
| Pralnacasan | ICE inhibitor (oral) |
| Verciniron | CCR9 blocker - Tc in gut for chromes |
| Marimastat | TACE/MMP inhibitor (MS SE) |
| NFkB inhibitors for TNFa | glucocorticoids thalidomide curcumin |
| Ertanercept | TNFR Ab fusion protein |
| Rituximab MEDI-155 | CD20 on Bc |
| Zieluton | inhibits leukotrienes |
| Infliximab | anti-TNF mAb (hu Fc & mu Fv) |
| Adalimumab | Fully hu anti-TNF |
| certolizumab pegol | PEGylated Fab fragment of TNFa |
| PEGylation | ↑ stability ↓ renal clearnace |
| Drawbacks of immunotherapy for TNFa | - immunogenic (∴ humanise) - short plasma T1/2 (∴ PEG) - need to IV admin - Infection risks (latent TB) - expensive |
| Onercept | PEG TNF binding protein (discontinued) |
| Ruxolitinib | JAK 1/2 inhibitor |
| Tofacitinib | Orally active JAK inhibitor (RA w/ MTX) |
| nedocromil | sodium cromoglycate topical for nose & eyes Mast cell stablaliser: inhibit mediator release only effective in 50% of population but treats early and late phase asthma |
| prednisolone budsonide | inhibits NFkB ∴ leuk migration via chemotaxis glucocorticoids |
| Altrakincept | soluable recombinant IL-4 dissapointing PIII |
| Pitrakinra | IL-4 variant ↓ late phase responses |
| Librikizumab | anti-IL-13 mAb effects secretion of epithelium only really helps FEV1 improvements |
| Ustekinumab | hu mAb |
| ketotifen | H1 antagonist & mast cell stabliser opthalmic and oral also leukotriene and PDE antagonist Maybe H4 activity: chemotaxis |
| Omalizumab | anti-IgE for allergic athmatics: NICE in sterioid resistants binds Fc needs to be taken for a while and expensive |
| anti-IL-4 | Altrakincept: soluable recombinant IL-4 receptor Pitrakinra: IL-4 variant |
| Lebrikizumab | IL-13 mAb effects secretion of epithelium |
| Mepolizumab | anti-IL5 for eosinophilic dermatis |
| Braikinumab | IL-12/23 mAb |
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