91927
Description
Flashcards by tanitia.dooley, updated more than 1 year ago
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Created by tanitia.dooley
over 12 years ago
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| Question | Answer |
| What are alpha and beta sugars? | If OH on same face as anomeric carbon (cis)= beta/ If on opposite face (trans)=alpha |
| What location defines a D and L sugar? | If OH on left=L on right=D |
| What is an epimer? | a diastereoisomer that differs in configuration at only one of the stereogenic centres |
| What is an anomer? | A type of an epimer that differs in configuration at the anomeric position |
| How does metabolism help excretion of drugs? | By increasing polarity and water solubility of the drugs |
| glucose+glucose= | maltose |
| glucose+fructose= | sucrose |
| Describe the process of mass spectrometry | the sample is vaporised and high energy electrons are fired at it causing part of the sample to be ejected=charged ion. A detector sorts charged ions into the relative mass-to-charge ratios and determines the relative amounts of each |
| what is a base peak? | Most intense signal which arise from bond cleavages that occur readily |
| Name two unfavourable fragments | CH3+ and H+ |
| What would be seen in a mass spec if there was an aromatic next to a Ch2? | peak at 91 due to [C7H7]+ and a peak at 65 due to loss of ethane |
| What is the molecular peak for an acylium cation on a mass spec? [COCH3]+. why is this stable? | 43 because cleaving next to a carbonyl is stable because +ve charge can be delocalised onto both oxygen and carbon so more spread out |
| What is the peak found for a phenyl cation? [C6H5]+ | 77 |
| name some monoisotopic elements? | F, I, P |
| What elements have a low abundance of other isotypes? | H + N |
| What elements have variations? | Cl, Br, S, Si, C |
| What does a 75:25% ratio suggest? | Cl |
| What does a 50:50% ratio suggest? | Br |
| What is MALDI? | softer technique, produces molecular ion with one positive charge-molecular weight of molecular more easily determined |
| What is ESI? | Softer technique, adds protons instead of electrons, produces multiple charges meaning multiple m/z values for same molecule |
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