Exam 2: Meglitinides

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Mind Map on Exam 2: Meglitinides, created by Jasper McClellan on 10/07/2022.
Jasper McClellan
Mind Map by Jasper McClellan, updated more than 1 year ago
Jasper McClellan
Created by Jasper McClellan over 3 years ago
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Resource summary

Exam 2: Meglitinides
  1. Pharmacokinetics
    1. Rapid absorption & elimination
      1. Metabolized in the liver
        1. Biliary excretion
        2. Pharmacological action
          1. Increase pancreatic insulin production during and after meals
          2. Adverse effects
            1. Hypoglycemia
            2. Contraindications
              1. Renal Impairment
                1. Hepatic impairment
                2. Drug Interactions
                  1. Gemfibrozil (Lopid) inhibits metabolism, causing hypoglycemia
                  2. Nursing Interventions
                    1. LFTs/Cr at baseline
                      1. 2-hr post-prandial glucose
                      2. Extra information
                        1. No more than 4 doses per day
                          1. Repaglinide
                            1. Take no more than 30 min before a meal.
                              1. Skipping a dose = Skipping a meal Add a dose if adding a meal
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