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retinoblastoma

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Paediatrics (Malignancy) Mind Map on retinoblastoma, created by v.djabatey on 31/01/2014.
v.djabatey
Mind Map by v.djabatey, updated more than 1 year ago
v.djabatey
Created by v.djabatey over 11 years ago
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Resource summary

retinoblastoma
  1. malignant tumour of retinal cells
    1. rare
      1. but = 5% of severe renal impairment in kids
      2. an affect one or both eyes
        1. all bilat tumours (& 20% of unilat) are hereditary
          1. susceptibility gene
            1. chromosome 13
            2. dominantly inherited, but incomplete penetrance
              1. most cases present 0-3 years old
                1. kids from families w/ hereditary form
                  1. regular screening from birth
                  2. clinical features
                    1. white pupillary reflex
                      1. commonest presentation
                      2. squint
                      3. Ix
                        1. under anaesthetic
                          1. MRI
                            1. examination
                            2. NO BIOPSY
                            3. Rx
                              1. aim to cure but preserve vision
                                1. Rx based on ophthalmological findings
                                  1. enucleation of eye
                                    1. for more advanced disease
                                    2. chemo
                                      1. in bilat disease
                                        1. shrink tumour
                                          1. fb local laser Rx to retina
                                          2. radiotherapy
                                            1. mostly for Rx of recurrence
                                              1. can be used in adv disease
                                            2. tumours often multifocal
                                              1. most are cured but many visually impaired
                                                1. sig risk of 2nd malignancy esp sarcoma among hereditary retinoblastoma survivors
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