10348718
Description
Flashcards by Amanda Lemmond, updated more than 1 year ago
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Created by Amanda Lemmond
about 8 years ago
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| Question | Answer |
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Image:
Blood (binary/octet-stream)
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Blood: -erythrocytes -neutrophils -platelets |
| Erythrocytes: -erythrocytes -nucleus of endothelial cells | |
| Monocyte: -oval/kidney shaped nucleus -agranulocyte | |
| Eosinophil: -cytoplasmic granules in eosinophil -bilobed nucleus | |
| Basophil: -cytoplasmic granules in basophil -bilobed nucleus (U or S-shaped) | |
| Lymphocyte: -round/slightly indented large nucleus -B cell, T cell, and NK cell | |
| Neutrophil: -multilobed (3-5) nucleus connected by nuclear strands | |
| Megakaryocyte: -mutilobed nucleus, may contain multiple sets of chromosomes | |
| Sickle-cell: -more fragile than normal erythrocyte -only lives ~20 days (difficult for erythropoiesis to keep up) -results: anemia, jaundice | |
| Plasmodium falciparum (Malaria): -Malaria caused by Plasmodium protist infecting RBCs -RBC become more fragile->anemia -Toxins build up in RBC, causing cytokine release by macrophages->fever, sweating *Sickle-cells have less volume to hold Plasmodium/fewer binding sites | |
| Blood Type A | surface antigen A anti-B antibodies in plasma |
| Blood Type B | surface antigen B anti-A antibodies in plasma |
| Blood Type O | no antigen anti-A antibodies anti-B antibodies (O- universal donor) |
| Blood Type AB | antigen A antigen B no antibodies (AB+ universal recipient) |
| Agglutination | Clumping of erythrocytes; occurs if an antigen is mixed with its corresponding antibody ex: Type A donor (antigen A) and Type B recipient (anti-A antibodies) |
| Rh Factor | Blood is Rh+ if surface antigen D is present Rh- if no surface antigen D Rh- can donate to Rh+ |
| HbF | Fetal Hemoglobin: -alpha and gamma subunits -present at birth, falls to 1-2% by age 1 (normal adult level) |
| O2 binding and HbF | -HbA-O2 binding impeded by DPG -DPG binds more easily to beta than gamma subunit -HbF-O2 affinity decreases much less with DPG than HbA |
| HbF and Sickle-cell | -Sickle-cell caused by mutation in beta-chain -Increasing HbF production->decrease symptoms -hydroxyurea inhibits HbA production; gamma subunits interfere w/hemoglobin crystallization, inhibiting sickle-cell shape |
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