5338133
Description
Flashcards by Amaal Salhieh, updated more than 1 year ago
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Created by Amaal Salhieh
over 9 years ago
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| Question | Answer |
| MOMP | MOM P has chlamydia |
| #1 cause of blindness (Be specific) | Chlamydia trachomatis Serovars A, B, C |
| Fitz-Hugh-Curtis is associated with... | C. trachomatis & N. gonorrhoeae |
| What is Fitz-Hugh-Curtis syndrome? | bacteria escaping thru fallopian tube, causing perihepatitis |
| Reiter Syndrome | reactive arthritis 80% of men with reactive arthritis have C. trachomatis |
| Lymphogranuloma Venerum cause (be specific) | C. trachomatis Serovars L1-L3 |
| C. trachomatis is neonates | neonatal conjunctivitis purulent discharge, eyelid swelling, conjunctival scarring may develop c. trachomatis pneumonia |
| Staccato cough is associated with... | infant pneumonia (2-3 weeks of age) due to chlamydia trachomatis |
| C. trachomatis Diagnosis | NAAT Antigen Detection - MOMP or LPS |
| C. trachomatis Treatment | For uncomplicated.. Azithromycin (1000 mg) x1 or Doxycycline x7 days Probably should give ceftriaxone in case of gonorrhae |
| N. gonorrhoeae micro | Aerobic, gram negative cocci Oxidase positive Can't grow on blood Grows on chocolate with 5% CO2 "When you're GONorrhoeae, I need air, and I have to eat a lot of chocolate. & I can't help but hyperventilate" |
| N. gonorrhoeae Virulence Factors | PPOL Pili - to attach to nonciliated epithelium PorB - prevents phagolysosome fusion Opa - mediates attachment to host cells LOS - Lipd A & core oligo (lacks O-antigen) "Opaaaaa! I attached to the host" (insert Greek accent) |
| Clinical Man. of Clap in men | Symptomatic acute urethritis |
| Clinical Man. of Clap in Women | Most asymptomatic Cervicitis, Urethritis, PID, Fitz-Hugh |
| Prophylactic ointment for neonates to prevent opthalmia neonatrium | erythromycin ointment |
| N. gonorrhoeae Diagnosis | NAAT Culture for susceptibility Microscopy - PMN with IC gram neg diplococci |
| N. gonorrhoeae Treatment | Ceftriaxone Cover Co-infection with Azithromycin |
| Treponoma pallidum Micro | Spirochete w/ polar flagella at each end Need to use darkfield microscopy |
| Syphilis Phase 1 | Site of infection (chancre) painless ulcer |
| Syphilis Phase 2 | Disseminated disease Rash Lymphadenopathy Condyloma latum (raised gray lesions in mucous membranes) Neurosyphilis (asymptomatic) |
| Syphilis Late Phase | Involvement of multiple sites Neurosyphilis Aortitis Gummas Such a NAG |
| Argyll-Robertson pupil | Accomodation, but no pupil reflex to light Syphilis Due to Tabes dorsalis |
| Congenital syphilis | Hepatomegaly and jaundice Snuffles Lymphadenopathy Hutchinson Teeth Saber shins |
| List the nontreponemal tests | Antibodies to caridolipins VDRL RPR |
| List the Treponemal Tests | Antibodies to specific treponemal antigens FTA-ABS (Ab-Absorption) TP-PA (particle agglutination) TP-EIA |
| Syphilis Treatment | Penicillin "Syft through the box of Pencils" Alternatives: Doxy or Azith (like in chlamydia) Only penicillin can be used for neurosyph!! |
| Jarish-Herxheimer Reaction | Febrile Rxn w. headache, myalgias after taking penicillin Syphilis |
| Chancroid micro | aka Haemophilus ducreyi gram neg coccobacilli Can grow on specialized agar (Hb, Abx) |
| Chancroid Clinical Man. | 5-10d incubation Tender erythematous papule-->pustule-->ulcer Inguinal lymphadenopathy |
| Chancroid Diagnosis | Culture ulcer base Requires specialized media |
| Chancroid Treatment | Macrolide or Ceftriaxone (just 1 does of either) People Chanc (shank) people because they macroLIDE or tried to kill them with an cefetriAXone) |
| Granuloma inguinale | aka Klebsiella granulomatis aka Donovanosis South America, Caribbean, India, Australia |
| Granuloma inguinale Clinical Man. | Subcutaneious genital nodules or inguinal area Typically lacks inguinal lymphadenopathy |
| Granuloma inguinale Diagnosis | Tissue sample for Donovan bodies to see bacteria in phagocytes |
| Granuloma inguinale Treatment | Azithromycin Granny gives no aZITHromycin about you. She does what she wants, shows up and gives you a beefy-red ulcer. |
| HSV Pathogeneisis | Binds to heparan sulate Replicates in epithelial cells and causes lytic infection at site Establishes latency in neurons Blocks TAP protein and goes cell2cell |
| Oral herpes | HSV-1 or 2 ginviovostomatitis - oral lesions can have pharyngitis |
| Encephalitis with HSV | involves temporal lobe with RBCs in CSF any age can develop this fever, headache, seizures, focal neurologic signs |
| HSV Diagnosis | PCR Viral culture of vesicular fluid DFA Serology (for primary) Biopsy (3 Ms- margination, molding, multinucleation) |
| HSV Treatment | nucleoside analogues that inhibit viral DNA polymerase Acyclovir, Valacyclovir, Penciclovir, Famciclovir *Substrate for DNA polymerase |
| HPV micro | naked dsDNA |
| Cutaneous Warts Treatment | Imiquimod or interferone Topical Cidofovir |
| Trichomoniasis Treatment | Metronidazole Get that TRICHomoniasis off the Metro |
| pHs with vulvovaginitis | Trichomoniasis - >4.5 Candida - pH normal (4 - 4.5) |
| Candida Vulvovaginitis Treatment | Nystatin or azoles Candy is Nasty and an Az-hole |
| Bacterial Vaginosis Treatment | Metronidazole Get the girl with the "fishy odor" off the Metro (along with that TRICH) |
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